NSAIDs are known to have adverse effects that could potentially lead to which of the following?

NSAIDs, or non-steroidal anti-inflammatory drugs, are widely used medications that can provide significant relief from pain and inflammation. However, one of the most serious concerns associated with their use is the potential for cardiovascular events.

Research has shown that NSAIDs can increase the risk of heart attacks and strokes, especially with prolonged use or in patients with pre-existing cardiovascular conditions. This is attributed to the drugs' effects on the balance of prostaglandins, which play a crucial role in maintaining cardiovascular function. Specifically, NSAIDs can lead to increased blood pressure and promote fluid retention, both of which contribute to cardiovascular strain.

The other options present different concerns: altered mental status is generally associated with factors like medications that affect cognitive function or metabolic abnormalities, while adrenal insufficiency is not typically linked to NSAID use. Liver toxicity can occur with some medications, but it is not a common adverse effect associated with NSAIDs compared to their cardiovascular risks. Therefore, the potential for NSAIDs to contribute to cardiovascular events is well-supported by clinical evidence, making it the correct answer among the choices provided.